Parental Age and Autism Spectrum Disorders

Posted on: 17 Iulie, 2013

AITAERIK THORLUND PARNER, MSC, PHD, SIMON BARON-COHEN, PHD, MARLENE B. LAURITSEN, MD, META JØRGENSEN, MD, LAURA A. SCHIEVE, PHD, MARSHALYN YEARGIN-ALLSOPP, PHD, AND CARSTEN OBEL, PHD

PURPOSE: We sought to study the possible association between parental age and autism spectrum disorder (ASD) by using both a cohort design and a sibling design.

METHODS: Our cohort included all singleton births in Denmark from January 1, 1980, through December 31, 2003, a total of 1,311,736 children. Cases of ASDs were obtained from the Danish National Psychiatric Register using International Classification of Diseases (ICD)-8 and ICD-10.

RESULTS: A total of 9556 children were diagnosed with an ASD. Both maternal and paternal age were associated with a greater risk of ASD in the offspring (hazard ratios ranging from 1.21 (1.10–1.34) to 1.65 (1.09–2.48) depending on combinations of parental age categories; !35, 35–39, and 40þ years). For mothers younger than 35 years, the risk of ASD increased with increasing father’s age group. For fathers younger than 35 years, the risk of ASD increased with increasing maternal age.

CONCLUSIONS: We found an association between parental age and ASD in the cohort study, but the combined underlying mechanisms through which paternal and maternal age impact ASD risk do not seem to act synergistically. The results of the sibling analysis suggest that the association between parental age and ASD found in the cohort study cannot be accounted for by common genetic and environmental factors. Ann Epidemiol 2012;-:-.  2012 Elsevier Inc. All rights reserved.
KEY WORDS: ASD, Autism Spectrum Disorder, Effect Measure Modification, Interaction, Maternal Age,
Paternal Age.

Received September 1, 2011. Accepted December 31, 2011. Published
online xxxx, xxxx.
 2012 Elsevier Inc. All rights reserved. 1047-2797/$ – see front matter
360 Park Avenue South, New York, NY 10010 doi:10.1016/j.annepidem.2011.12.006

Continuarea: http://docs.autismresearchcentre.com/papers/2012_Parner_etal_AnnalsofEpidemiology_ParentalAge.pdf

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